Retinoids in chemoprevention and differentiation therapy
نویسندگان
چکیده
منابع مشابه
Retinoids in chemoprevention and differentiation therapy.
Retinoids are essential for the maintenance of epithelial differentiation. As such, they play a fundamental role in chemoprevention of epithelial carcinogenesis and in differentiation therapy. Physiological retinoic acid is obtained through two oxidation steps from dietary retinol, i.e. retinol-->retinal-->retinoic acid. The latter retinal-->retinoic acid step is irreversible and eventually mar...
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Chemoprevention is the use of noncytotoxic therapeutic intervention at the early stages of carcinogenesis against the development and progression of mutant clones to invasive cancer. Retinoids are the most extensively studied and one of the most prominent groups of chemopreventive agents to reach clinical trials. Acute promyelocytic leukemia is the first human malignancy that is successfully tr...
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-___ Abstract Human trials of cancer chemoprevention employing antitumor promoter retinoids are currently progressing worldwide and are targeting mainly skin, lung, uterine cervix or breast cancers. Although the inhibitory effects of various synthetic retinoids on experimental cancers and tumor-derived cell lines are promising, several problems with adverse effects such as mucocutaneous disorde...
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Carcinogenesis is a complex disease which involves environmental and genetic factors as a predisposing cause that bring alterations in the microstructure of the cell. Vitamin A is considered as an essential micronutrient whose role is extensively known in physiologic and elusive in pathological state associated with chemopreventive and therapeutic modalities. Retinoids, form of Vitamin A, have ...
متن کاملSystemic retinoids: chemoprevention of skin cancer in transplant recipients.
Solid organ transplant recipients (OTRs) have an increased incidence of skin cancer, resulting in significant morbidity and mortality post-transplantation. Chemoprevention strategies are focused on reducing and delaying the development of skin cancer in these patients. Although systemic retinoids are widely used in OTRs, few randomized controlled trials have been performed. Limited data suggest...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/21.5.271